| 1 |
Author(s):
Prasanta Ghadei, Dr. Sujit kumar Jally.
Research Area:
Environmental Science
Page No:
1-11 |
Assessment of Physicochemical Properties of Upper Lake, Bhopal: A Comprehensive Literature Review
Abstract
Lake degradation is a critical global issue, with human activities having a significant negative impact on lakes and reservoirs. Eutrophication, the process of adding nutrients, silt, and other organic material to a lake, can result in increased algal and rooted aquatic plant production, altering the biological stability of the lake and tank ecosystems. Water pollution is a big issue in developing countries, with 35% of urban and 65% of rural Indians drinking contaminated water, which leads to diseases like diarrhea, cholera, dysentery, typhoid, amoebiasis, jaundice, and Enterobacteriaceae. The Upper Lake in Bhopal, India, is facing severe threats from various anthropogenic activities, such as deforestation, intensive agricultural practices, industrial growth, and sewage. The water quality of the lake can be assessed using various physicochemical parameters, like surface water temperature, pH, total hardness, alkalinity, BOD, COD, chloride, and nitrate. However, literature reviews have found that most variables are not at a standard level, indicating a need for proper attention and management of lake water.
| 2 |
Author(s):
Monoj Maiti, Dr. Sandip Kumar Sinha.
Research Area:
Human Physiology
Page No:
12-24 |
Physiological Hazards of Deep-Sea Fisherman of Purba Medinipur District, West Bengal, India: An overview
Abstract
From July to March of each year, deep-sea fishermen harvest a variety of sea fish. Fishermen operate in challenging meteorological conditions, such as variations in the pH of saltwater, variations in the quantities of carbon dioxide and oxygen, salinity of the water, etc. Their eating habits differ from those of their home surroundings, and they tend to work a lot and have trouble sleeping. These individuals also routinely consume alcohol and nicotine as part of their hobbies. According to the literature review, there isn't a comprehensive, scientific database on the physiological risks that the people living in the coastal Purba Medinipur area of West Bengal face. Deep-sea fishermen may experience numerous physiological and nutritional alterations as a result of this dangerous employment. Thus, we make an effort to learn as much as we can about the physiological conditions and other details of the residents of this community. For the deep-sea fisherman health study, many physiological and anthropometric factors, haematological parameters, biochemical indicators of blood and urine, and dietary assessment are crucial. We read a tonne of research publications, review works, and newspapers about deep-sea fisherman in addition to using several search engines (Pub made, Google Scholars, etc.) to gather information. Following an investigation of various health-related data from multiple sources, it has been determined that deep-sea fisherman may experience changes in all of their nutritional and health-related indicators when fishing.
| 3 |
Author(s):
Dr. Gade. Venkatesham, Mrs. Prasanna Lakshmi Murapaka, V. V. Madhuvan, Dr. P. Akhila Swathanthra.
Research Area:
Environmental Engineering
Page No:
25-35 |
Composting for a Cleaner India Comparing Technologies for Sustainable Waste Management
Abstract
India, as one of the most populous countries, faces an ever-growing challenge in managing its municipal solid waste (MSW). With over 40-50% of Indian MSW being biodegradable organic matter, composting has emerged as a viable solution for sustainable waste management. This article, based on the study “Assessment of the Quality of IMC Composting Produced from Municipal Solid Waste,” explores the comparative efficacy of different composting techniques -Windrow Composting (WC), Vermicomposting (VC), and Inoculated Microbial Composting (IMC). The analysis is grounded in laboratory testing of compost samples collected from various municipal corporations and assessed based on Fertilizing Index (FI) and Clean Index (CI) parameters. The findings offer a deeper understanding of compost quality, environmental safety, and potential for marketability, thereby shaping India’s journey towards a cleaner and more sustainable future.
| 4 |
Author(s):
Somendra Kumar, Tirthankar Choudhury, Rajesh Kumar, Sheela Kushwaha, Shiv Gulam.
Research Area:
Pharmaceuticals
Page No:
36-46 |
A Review on Discovering the Satisfying Potentials of Crassula Ovata: From Modern Usages to Medication Presentations
Abstract
Crassula ovata, more commonly referred to by the name jade has received a lot of attention recent years due to its diverse potential for therapeutic applications as well as environmental sustainability and biotechnological breakthroughs. This review summarizes the current research on Crassula ovata, highlighting its medicinal properties, such as antioxidant, anti-inflammatory, anti-microbial and wound healing properties that support its long-standing applications and offer promising avenues for the development of pharmaceuticals. Furthermore, the plant's use in the field of environmental remediation and as an element in urban green infrastructure is examined, highlighting its value for green roofs and phytoremediation applications. Despite its numerous applications, some challenges like the need for a comprehensive toxicological assessment and the study of its bioactive components are recognized. The future research direction is suggested with a focus on closing the gaps in our current knowledge, investigating the plant's genetic and molecular foundation for therapeutic properties, and dealing with ethical and regulatory concerns. This review demonstrates how important it is to use a broad approach for exploring the full spectrum of Crassula ovata's benefits and making sure that it is sustainable and preservation for the future.
| 5 |
Author(s):
Dr. Sachin Yashwant Shigwan.
Research Area:
Renewable Energy Engineering
Page No:
47-54 |
Impact of Solar-Powered Electric Vehicle Charging Stations: Environmental, Economic and Social Perspectives
Abstract
The rapid electrification of road transport is a central pillar of global climate action, but the true environmental benefits of electric vehicles (EVs) depend critically on how the electricity used for charging is produced. Solar-powered EV charging stations (solar EVCS) are an attractive, practical solution that pairs distributed renewable generation with charging infrastructure, reducing lifecycle emissions, improving energy resilience, and creating economic and social value. This paper synthesizes evidence from an in-house impact report on solar EVCS prepared by Dr. Sachin Y. Shigwan and Green India Initiative, alongside peer-reviewed studies, government handbooks and industry analyses. It documents the greenhouse gas and air-pollutant reductions achievable with solar EV charging, evaluates techno-economic viability and business models, explores employment and social impacts, examines technological integration needs (including storage and smart charging), and identifies policy and implementation recommendations for scaling solar EVCS in India and comparable markets. The evidence indicates that solar EVCS can materially advance climate, public-health and development goals, but meaningful scale will require coordinated policy support, tailored financing, and continued technical innovation. NITI AAYOG
| 6 |
Author(s):
Nabila Shamayil, Shifa, Aqsa Bakhtawar Khan, Ekta Tiwari, Pawan Kumar Doharey, Sarad Kumar Mishra.
Research Area:
Life Science
Page No:
55-76 |
Pesticide-Induced Oxidative Stress and Cancer: Mechanistic Insights and Public Health Implications
Abstract
Pesticides are widely used in modern agriculture to improve crop yield and prevent pest-related losses. However, increasing epidemiological and experimental evidence links chronic pesticide exposure with cancer development. One of the critical mechanisms implicated in this association is oxidative stress. Pesticides induce excessive reactive oxygen species (ROS) formation overwhelming the antioxidant defense systems and leading to cellular damage, lipid peroxidation, DNA mutation, and ultimately carcinogenesis. ROS-mediated signaling in addition to direct genotoxicity, it also disrupts normal cell cycle regulation, alters gene expression and suppresses tumor suppressor pathways, that leads to facilitating malignant transformation. The co-ordinated behaviour of both enzymatic and non-enzymatic antioxidants, along with its mitochondrial dysfunction that's further aggravates the oxidative imbalance. This review aims to explore the biochemical interplay between pesticide-induced oxidative stress and cancer, with a focus on molecular pathways, types of pesticides involved, antioxidant disruption, and potential biomarkers of exposure and effect. Pesticide exposure and oxidative damage of cell discusses its recent findings from in vitro and in vivo studies that strengthen the causal relationship between them. To mitigate the effect of cancer in the human population, we need to have proper knowledge of these interactions for the betterment of public health surveillance, regulation of policy with more future therapeutic interventions. Pesticide-related cancer risks will be reduced by the greater awareness with sustainable agricultural practices and safer alternatives.
| 7 |
Author(s):
Heriberto Rodríguez Frausto, Federico I. De La Colina FLORES, Tzitzi T. De La Colina García, Paul A. De La Colina García.
Research Area:
Veterinary Science
Page No:
77-84 |
Competence without Competitiveness: Integrating Entrustable Professional Activities with Cultural–Historical Activity Theory for Veterinary, Animal, and Health Sciences
Abstract
Competency-based education in veterinary, animal, and health sciences requires an approach that privileges competence and cooperation over competitiveness. This manuscript proposes and develops a scientific–philosophical model that synthesizes Entrustable Professional Activities (EPAs) with Cultural–Historical Activity Theory (CHAT) to support workplace-based learning across real settings such as clinics, farms, laboratories, slaughterhouses, and public-health agencies. The argument proceeds from the claim that learning ought to be oriented not only toward transforming objects—improving welfare indices, reducing disease prevalence, strengthening data integrity—but also toward forming subjects and communities capable of redesigning their tools, rules, and media. After reviewing key developments in the EPA literature and in CHAT, we articulate a method of conceptual integration that yields a coherent delegation grammar linked to activity-system analysis. We then narrate the supervision continuum in veterinary terms, exemplifying the five EPA supervision levels, including widely used expanded sublevels, in small-animal, equine, food-animal, public-health, and research contexts. A design for individualization is presented that draws on Self-Determination Theory, Cognitive Load Theory, Deliberate Practice, Desirable Difficulties, and Universal Design for Learning. Finally, we propose a programmatic, formative assessment approach grounded in activity-theoretical analysis, where diverse evidence streams are aggregated into fair, transparent entrustment decisions. The framework is suitable for students, educators, professionals, and researchers, and it is intended to be deployed in real workplaces rather than confined to classrooms.
| 8 |
Author(s):
Hassan Abbas, Naeem Ejaz, Muhammad Aleem.
Research Area:
Civil Engineering
Page No:
85-96 |
A Comprehensive Water Balance Assessment of Northern Pakistan’s Catchment Based Using the Budyko Framework Approach
Abstract
This study presents a comprehensive hydrological evaluation of the Astore catchment(Northern Pakistan), integrating long-term observational data with advanced modeling techniques to assess water balance dynamics and runoff simulation accuracy. Spanning two decades (2000–2020), the dataset includes key parameters such as annual rainfall (1144 mm), actual evapotranspiration (278 mm), and groundwater recharge (494 mm), offering insights into the catchment’s hydrometeorological behavior. These variables are influenced by diverse environmental factors including topography, land use, soil composition, and microclimatic conditions. To simulate runoff and validate hydrological responses, a Budyko-based model was calibrated at both monthly and yearly scales. The optimization of parameters Smax, α1, α2, and d yielded high-performance metrics, with a Pearson correlation of 0.99, NNSE of 0.97, and RMSE of 0.02. These findings validate the model’s capability to replicate observed runoff patterns with remarkable precision. Visual comparisons between observed and simulated rainfall and runoff data underscore the model’s effectiveness in capturing seasonal variability and hydrological trends. Furthermore, sensitivity analysis revealed the model’s responsiveness to parameter changes, highlighting the importance of careful calibration for reliable predictions. The integration of empirical data and robust simulation techniques provides a valuable framework for understanding catchment-scale water dynamics. This approach supports improved forecasting, resource management, and environmental planning, particularly in regions vulnerable to hydrological extremes such as landslides and droughts. The findings contribute to the broader field of hydrological modeling by demonstrating the utility of Budyko-based frameworks in complex mountainous terrains.
| 9 |
Author(s):
Vibha Chandrakar, Neelam Soni, Vasu Verma, Arpita Soni.
Research Area:
Nutrition Science
Page No:
97-103 |
Processing And Preparation of Jam Using Hibiscus Sabdariffa (Ambadi) Calyx
Abstract
Hibiscus Sabdariffa flaunts ravishing crimson calyx and remarkably zesty flavor quite extensively making it a venerated tropical plant. Growing with large deeply cut leaves and showy flowers it is cherished for cooking purposes. Nutritional and sensory properties of Jam made from Hibiscus Sabdariffa calyx were developed and evaluated thoroughly. One control and three variations were prepared with different proportion of sugar and calyx. Significant differences in appearance color flavor taste were revealed between variations through sensory evaluation. Jam nutritional value was rich in calcium 211.7mg, iron 19.5mg, Calorie 322.04kcal and carbohydrate 75.25gm per 100gm essentially. Hibiscus Sabdariffa calyx Jam is a nutritious food product with improved sensory attributed over time consistently. Sensory evaluation shows significant improvements in appearance, texture and overall acceptability over time gradually. Product consistency and quality increase with reduced variability overtime generally. Hibiscus Sabdariffa is a valuable ingredient in food products offering benefits and sensory benefits simultaneously.
| 10 |
Author(s):
Dr. Dipak Ashok Zope, Prof. Nitin A. Kharche.
Research Area:
Physics
Page No:
104-113 |
Surface Modification of Semiconductor Nanoparticles for Enhanced Optical Performance
Abstract
Considering the fact that their electrical and optical characteristics are dependent on their size, semiconductor nanoparticles, which are sometimes referred to as quantum dots, have emerged as potentially useful materials. On the other hand, their actual applicability in optoelectronic devices, sensors, and bioimaging is frequently restricted due to surface-related flaws, nonradiative recombination, and poor stability under ambient circumstances. Surface modification schemes offer an efficient means of overcoming these obstacles by allowing for the alteration of the chemical and physical properties of nanoparticle surfaces. It has been demonstrated that some methods, including as ligand exchange, core–shell engineering, and surface passivation, may considerably improve the efficiency of photoluminescence, as well as charge carrier dynamics and environmental stability. In addition, functionalisation with organic and inorganic moieties not only enhances optical performance but also permits biocompatibility and selective targeting in biomedical applications. This is important since these properties are essential for biological applications. The promise of these modified nanostructures in next-generation solar cells, light-emitting diodes, photocatalysis, and quantum technologies has been brought to light by recent developments in controlled synthesis and surface engineering. The purpose of this work is to examine the role that surface modification plays in optimising the optical behaviour of semiconductor nanoparticles. The focus is on the present tactics, underlying processes, and future possibilities for the achievement of nanomaterials that are adjustable, stable, and suitable for application.
| 11 |
Author(s):
Saba khan , Dr. Neetu Yadav.
Research Area:
Nutrition Science
Page No:
114-122 |
Harnessing Nature’s Abundance: A Narrative Review on the Supremacy of Herbal Medicines
Abstract
Herbal remedies have played a crucial role in human health care for millennia and remain significant therapeutic resources in both traditional practices and contemporary medicine. Growing concerns over the side effects of synthetic drugs have heightened global interest in natural alternatives, which are often viewed as safer, more holistic, and cost-effective. This review brings together scientific insights on the pharmacological value of widely used herbs such as Aloe vera, Peppermint, Ginger, Chamomile, Lavender, Garlic, Turmeric, Lemon Balm, Thyme, Cilantro, Basil, St. John’s Wort, and Dandelion. Relevant literature was collected from PubMed, Scopus, and Google Scholar, with a focus on phytochemical composition, pharmacological mechanisms, and therapeutic roles. Evidence indicates that Aloe vera is effective in wound repair and oxidative stress reduction; peppermint supports gastrointestinal health; ginger provides anti-inflammatory and metabolic benefits; and chamomile and lavender exhibit calming and sedative properties. Garlic and turmeric demonstrate cardiovascular and anticancer potential, while lemon balm, thyme, cilantro, basil, St. John’s Wort, and dandelion offer antioxidant, liver-protective, and immune-enhancing effects. Despite promising outcomes, issues such as inconsistent dosing, safety evaluation, and limited clinical trials restrict their broader acceptance. Future studies should prioritize well-designed randomized trials and standardized formulations to promote the integration of herbal medicines into mainstream healthcare systems.
| 12 |
Author(s):
Dr. Ankhi Haldar, Dr.Pubali Dhar.
Research Area:
Nutrition Science
Page No:
123-134 |
Understanding Adiponectin Dynamics in Chronic Kidney Disease
Abstract
Adiponectin is an adipokine known for its insulin-sensitising effects, including the suppression of hepatic gluconeogenesis, enhancement of fatty acid oxidation, and promotion of glucose uptake. Within the kidneys, adiponectin is primarily localised to the arterial endothelium, smooth muscle cells, and capillary endothelium. Adiponectin might be considered a marker of many negative factors in chronic kidney disease.
The last few years have yielded a growing body of evidence that adiponectin is a multifunctional protein with anti-inflammatory, metabolic, anti-atherogenic, and reactive oxygen species (ROS)- protective actions. In recent years, accumulating evidence has highlighted adiponectin as a multifunctional protein with anti-inflammatory, metabolic, anti-atherogenic, and antioxidant (ROS-protective) properties. Moreover, adiponectin appears to exert a range of beneficial and direct effects on various renal cell types and kidney pathologies. Similarly, adiponectin has demonstrated numerous positive and direct actions in kidney diseases, as well as across multiple kidney cells. Data from extensive cross-sectional and cohort studies have shown a positive correlation between serum adiponectin levels and mortality in patients with chronic kidney disease.
This suggests a complex interaction between local adiponectin action, comorbidities, and uremic milieu. In this review, we explore the multifaceted role of adiponectin in chronic kidney disease, examining its physiological functions, pathological implications, and potential as a biomarker or therapeutic target.Keywords: Adiponectin, Biomarker, Comorbidities
Abbreviations: CKD- chronic kidney disease, EGRF- estimated glomerular filtration rate
| 13 |
Author(s):
KM Jyoti Mishra, Dr. Naveen Kumar Singh.
Research Area:
Biotechnology
Page No:
135-145 |
Biodegradable Polymers-Based Scaffolds for Wound Healing and Tissue Engineering
Abstract
Biodegradable polymers have gained significant attention as innovative materials for producing scaffolds used in wound repair and tissue regeneration. These scaffolds serve as temporary structures that aid cell attachment, multiplication, and specialization, while gradually decomposing into safe byproducts that are naturally absorbed or removed from the body. Natural polymers such as chitosan, collagen, alginate, and hyaluronic acid are valued for their biological activity, whereas synthetic polymers like polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), and poly(lactic-co-glycolic acid) (PLGA) are preferred for their predictable strength, durability, and adjustable degradation profiles.
The central focus of scaffold design is to imitate the body’s extracellular matrix (ECM), offering a balance of porosity, bioactivity, and mechanical stability. Advanced fabrication technologies, including electrospinning, freeze-drying, and 3D bioprinting, enable precise control over scaffold architecture. These approaches also make it possible to integrate growth factors, antimicrobial agents, or therapeutic molecules that accelerate wound closure, reduce infections, and encourage the regeneration of functional tissues.
Laboratory and animal-based evaluations are necessary to determine cytocompatibility, structural integrity, and degradation rates. With continuous progress in biomaterials and fabrication methods, biodegradable polymer scaffolds are emerging as vital tools for regenerative medicine. They not only enhance wound healing but also contribute to developing patient-specific solutions in tissue engineering and precision healthcare.
| 14 |
Author(s):
Prashant R. Chawla, Uma Adepally.
Research Area:
Biotechnology Engineering
Page No:
146-150 |
Optimizing Bioprocess Economics for Manufacturing of Vaccine: Pathways to Cost Reduction
Abstract
Cost reduction in vaccine manufacturing is a critical objective to sustain competitiveness and profitability while maintaining product quality, safety and efficacy. Increasing the selling prices is rarely feasible due to market pressures and regulatory restrictions, therefore, optimizing manufacturing costs is the preferred strategy. Manufacturing costs broadly comprise direct material costs, direct labor costs, and overhead costs, each of which presents unique opportunities for cost savings by up to 30%. This paper explores systematic approaches to reduce costs in vaccine production, such as adopting cost effective raw materials, optimization of labor utilization, minimizing product rejections and excess inventory, managing overhead costs, and streamlining of process steps. The discussion emphasizes that careful implementation of strategies that can reduce production costs, while maintaining compliance with Good Manufacturing Practices (GMP), regulatory standards, and product performance. By addressing both technical and operational aspects, the paper highlights practical measures that enable sustainable cost reduction without compromising the quality or accessibility of life saving vaccines
| 15 |
Author(s):
Aakansha Ravindra Patil, Rutik Asaram Hajare, Abhay Bajrang Jadhav, Kalpita Manik Patil, Kumudini Kisan Pandharkar.
Research Area:
Pharmaceuticals
Page No:
151-160 |
Development And Formulation of Probiotic Using Fermentation Method
Abstract
The present study focuses on the development and formulation of a probiotic using a fermentation-based approach with blueberry (Vaccinium corymbosum) and black rice (Oryza sativa L. indica). Plant extracts were prepared by Soxhlet extraction using 50% ethanol, followed by concentration with rotary evaporation and lyophilization. The extracts were combined in a 7:3 ratio (BB:BR) and fermented with Lactobacillus plantarum 2656 under controlled conditions to obtain a fermented product (FBBBR) with 60% yield. Antimicrobial activity of the formulation was assessed against Shigella boydii ATC 9207 using agar cup diffusion, resazurin-based minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays, confirming its inhibitory potential. Additionally, an orally disintegrating film (ODF) was formulated using carboxymethyl cellulose, gelatine, starch, and sorbitol as film-forming agents for the incorporation of the probiotic. The ODF was evaluated for swelling index, disintegration time in water and simulated saliva, pH, and probiotic viability during storage. Results demonstrated that the fermented extracts enhanced antimicrobial activity and maintained probiotic viability within the ODF matrix. Overall, this study highlights a novel formulation strategy that integrates natural bioactive extracts with probiotics, offering a promising functional nutraceutical delivery system with potential therapeutic benefits.
| 16 |
Author(s):
Not available .
Research Area:
Pharmacology
Page No:
161-181 |
This article has been withdrawn at the request of the authors.
Abstract
This article has been withdrawn at the request of the authors.
| 17 |
Author(s):
Dr. Kothwala Deveshkumar, Patel Hemant, Desai Mansi.
Research Area:
Medical Science
Page No:
182-189 |
A Comprehensive Evaluation of the Accuracy and Precision of In Vitro Diagnostic Devices: Analytical Methodologies, Laboratory Influences, and Regulatory Considerations
Abstract
In-vitro diagnostic (IVD) devices have been recognized as indispensable tools for disease detection, clinical monitoring, and therapeutic decision-making. Their diagnostic value is inherently dependent on the accuracy and precision of the results they produce. Accuracy is defined as the degree of conformity between a test result and the true or reference value, while precision refers to the consistency of repeated measurements under identical conditions. Inadequate performance in either metric may compromise clinical outcomes and patient safety. This review was undertaken to systematically evaluate the concepts, assessment methodologies, and regulatory standards related to the accuracy and precision of IVD devices. Emphasis was placed on laboratory-based evaluations to identify factors influencing diagnostic reliability. A comprehensive analysis of peer-reviewed literature and regulatory documents has revealed that multiple factors—including device design, reagent quality, operator handling, and environmental conditions—substantially impact accuracy and precision. Methodologies such as repeatability tests, inter-laboratory comparisons, and reference method comparisons were found to be essential for robust performance assessment. It was also observed that adherence to guidelines from regulatory bodies like the FDA, CLSI, and ISO improves diagnostic standardization. Moreover, calibration routines and quality control measures were shown to be critical in minimizing systematic and random errors. It was concluded that the assurance of diagnostic accuracy and precision requires a multidisciplinary approach encompassing engineering design, laboratory practices, and regulatory compliance. Future advancements in automation, sensor technology, and AI-driven analytics are expected to further enhance the performance and reliability of IVD devices.
